I don't see Ziggler dropping the title in a disappointing Christian-esque fashion, but I do see him dropping it, after a decent 3/4 month reign, as a result of AJ and Big E either costing him the title trying to help him out or screwing him over.
I can see the WWE fans getting behind him as a result of this, resulting in a face turn.
I don't see any reason why he should drop it at Extreme Rules. He's solid in the ring, he's charismatic, and he can dut a half decent promo. Plus he's worked hard since debuting in WE to earn this, so I don't see any reason why WWE would have him drop it anytime soon.